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The most com-mon small vessel disease in aging is arteriosclerosis/arteriolosclerosis (AS; see Figure 2.20). From thedata presented, it is obvious that the development and function of both types (innate andadaptive) of Tregs is complex. Potential genetic toxicity has beentested in both in vitro and in vivo assays.

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If there is a suspicion of abuse,the patient and caregiver should be interviewed sepa-rately.

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